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目的对比观察不同剂量瑞舒伐他汀治疗冠心病心力衰竭的疗效。方法将医院门诊部收治的诊断为冠心病心力衰竭患者80例采用双盲法分为常规组和大剂量组各40例。常规组给予一般剂量瑞舒伐他汀治疗,大剂量组使用大剂量瑞舒伐他汀治疗。对比2组血脂及心功能改善情况。血脂指标包括:低密度脂蛋白胆固醇-C(LDL-C)、总胆固醇(TC)、三酰甘油、高密度脂蛋白胆固醇-C(HDL-C)。心功能指标包括:心输出量、每搏输出量、左心室射血分数。结果用药后大剂量组低密度LDL-C、TC、三酰甘油水平均低于常规组,HDL-C水平高于常规组,差异均有统计学意义(P<0.05)。入院时2组患者心功能指标心输出量、每搏输出量及左心室射血分数水平差别无统计学意义(P>0.05)。服药后大剂量组较常规组患者心功能指标恢复好,差异有统计学意义(P<0.05)。结论大剂量瑞舒伐他汀能有效改善冠心病心力衰竭患者症状,恢复患者心功能。
Objective To compare the effects of different doses of rosuvastatin on patients with heart failure of coronary heart disease. Methods Eighty patients diagnosed as heart failure with coronary heart disease admitted to the hospital outpatient department were divided into two groups according to the double-blind method, 40 cases in each group. Routine group were given normal dose of rosuvastatin treatment, high-dose group with high-dose rosuvastatin treatment. Compare the two groups of blood lipid and cardiac function to improve the situation. Lipid markers include: LDL-C, TC, triglyceride, HDL-C. Cardiac function indicators include: cardiac output, stroke volume, left ventricular ejection fraction. Results The LDL-C, TC and triglyceride levels of high-dose LDL-C group were significantly lower than those of the conventional group (P <0.05). The levels of HDL-C were higher than those of the conventional group. There were no significant differences in cardiac output, stroke volume and left ventricular ejection fraction between the two groups on admission (P> 0.05). After taking medicine, the cardiac function index of high-dose group recovered better than that of routine group, the difference was statistically significant (P <0.05). Conclusion High-dose rosuvastatin can effectively improve the symptoms of patients with heart failure and restore the cardiac function.