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目的:探讨吗啡在小儿心内直视手术中的心肌保护作用。方法:20例行房室缺修补手术的患儿随机分成两组,吗啡组(M组)心肌停跳液中加吗啡2mmol/L,对照组(C组)常规的停跳液。比较术后低心排和严重的心律失常发生率,测定主动脉开放后2h、12h、24h磷酸肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白(cTnI)水平。结果:M组在主动脉开放后2h、12h、24h血cTnI、CK-MB的水平较C组明显降低(P<0.05)。结论:吗啡对小儿体外循环下的心肌有保护作用。
Objective: To investigate the myocardial protection of morphine in open heart surgery in children. Methods: Twenty children with atrioventricular tachycardia were randomly divided into two groups. Morphine group (M group) was given morphine 2mmol / L, and control group (C group) conventional cardioplegia. The incidences of low cardiac arrhythmia and severe arrhythmia were determined. The levels of CK-MB and cTnI were measured at 2h, 12h and 24h after aortic opening. Results: The levels of cTnI and CK-MB in group M were significantly lower than those in group C at 2h, 12h and 24h after opening of aorta (P <0.05). Conclusion: Morphine has a protective effect on cardiopulmonary bypass in children.