论文部分内容阅读
目的分析癫癎患儿苯巴比妥(PB)血药质量浓度的影响因素。方法对癫癎患儿83例进行103次血样检测,年龄1.5个月～16岁,采用高效液相色谱分析法测定其稳态血液谷质量浓度。采用多元逐步回归分析法分析。结果给药剂量、体质量对PB血药质量浓度影响有显著差异(P<0.05)。如果用CPB代表PB血药质量浓度(mg/L),D代表用药剂量(mg/kg),W代表体质量(kg),则多元回归方程为CPB=-1.711+4.194D+0.199W(r=0.661P=0)。结论尽管PB浓度受多种因索影响,但以用药剂量和体质量影响最明显,在无血药质量浓度监测条件医疗单位,大致可利用目标浓度和体质量来计算用药剂量。
Objective To analyze the influential factors of blood mass concentration of phenobarbital (PB) in children with epilepsy. Methods 83 cases of children with epilepsy were tested for blood samples for 103 times, ranging in age from 1.5 months to 16 years old. The steady-state blood trough concentrations were measured by HPLC. Using multiple stepwise regression analysis. Results The dose and body weight had significant difference on the PB concentration (P <0.05). If CPB represents the PB blood concentration (mg / L), D represents the dose (mg / kg) and W represents the body weight (kg), the multiple regression equation is CPB = -1.711 + 4.194D + 0.199W = 0.661P = 0). Conclusion Although the concentration of PB is influenced by many factors, the dose and body mass influence the most obviously. In the medical unit without blood mass concentration monitoring, the target concentration and body mass can be roughly used to calculate the dosage.