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The thermal Claisen rearrangement of O-allyl substituted isotetronic acids 1 was successfully carried out within a glass microreactor operated with temperature at 150℃and a flow rate of 1 mL/h.The strategy provides an efficient alternative way toβ-allyl substituted isotetronic acid derivatives 2 in high yields with much accelerated reaction speed.
The thermal Claisen rearrangement of O-allyl substituted isotetronic acids 1 was successfully carried out within a glass microreactor operated with temperature at 150 ° C and a flow rate of 1 mL / h. The strategy provides an efficient alternative to β-allyl substituted isotetronic acid derivatives 2 in high yields with much accelerated reaction speed.