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目的 :探讨海拔 540 0m高原富氧对纠正低氧大鼠学习记忆功能持续时间的作用 ;方法 :3月龄Wistar大鼠 2 2只随机分为低氧组 (1 2只 )和富氧组 (1 0只 ) ,低氧组在模拟海拔 540 0m的低压舱内 2 4小时 ,富氧组在模拟海拔 540 0m的低压舱内 1 2小时富氧(2 7%的氧混合气 ) 1 2小时 ,于出富氧室即刻、2h、4h、6h分别进行Morris水迷宫试验测定大鼠的学习记忆能力 ;结果 :与低氧组比较 ,富氧组寻找平台潜伏期的时间缩短 ,低氧组运动水迷宫游泳呈周边型 ,富氧组呈向平台型 ,出富氧室 4h ,学习记忆功能仍明显高于急性缺氧组 ;结论 :富氧能改善缺氧大鼠的学习记忆功能 ,增加机体的氧储备 ,在高原军事医学中有非常重要的应用价值
Objective: To investigate the effects of oxygen enrichment at altitude of 540 0 m on the learning and memory function in hypoxic rats. Methods: Twenty-two 3-month-old Wistar rats were randomly divided into hypoxia group (12 rats) and oxygen- 1 0). In the hypoxia group, 24 hours were simulated in the low-pressure cabin with an altitude of 540 meters and in the low-pressure cabin with an altitude of 540 meters, the oxygen-rich group was enriched with oxygen (27% oxygen mixed gas) for 12 hours , Respectively. Morris water maze test was used to measure the learning and memory abilities of rats immediately after 2 hours, 4 hours and 6 hours respectively. Results: Compared with the hypoxia group, the incubation time of the oxygen- The labyrinth swimming peripheral type, oxygen-enriched group showed platform type, the oxygen-enriched room 4h, learning and memory function is still significantly higher than the acute hypoxia group; Conclusion: oxygen enrichment can improve the learning and memory function of hypoxic rats, Oxygen reserves, in the plateau military medicine has a very important value