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中药复方有别于单味的关键,在于发挥配伍之所长,所谓“药有个性之特长,方有合群之妙用”。这里提出有关复方配伍关系中一些需要解决或重视的基本问题。 一、协同和拮抗的概念:近年来,复方药理研究日益受到重视,而配伍关系的研究也不少。但究竟什么是协同,什么是拮抗,这一基本概念尚有待明确。 1.作用强度:合并用药时,其作用超过两药效应简单相加的期望值时,称为协同,反之,则为拮抗。但如何估算这一期望值,在认识上还不一致。如 ①brgi氏公式:设A、B两药单独作
The key to a Chinese medicine compound is different from the single flavor, which is to play the role of compatibility, and the so-called “pharmacy has the specialty of personality, only the magical use of the group.” Here are some basic issues that need to be addressed or valued in relation to compound compatibility. First, the concept of synergy and antagonism: In recent years, compound pharmacology research has received increasing attention, and there are many researches on compatibility. But what exactly is synergy and what is antagonism? This basic concept remains to be determined. 1. Intensity of action: When the drug is combined, its effect exceeds the expected value of the simple addition of the two drug effects and is referred to as synergy; conversely, it is antagonistic. However, how to estimate this expectation value is still not consistent in understanding. For example, 1brgi’s formula: Let A and B be used separately