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目的:探讨高原地区不同生活环境下藏族人群血脂代谢特点及与对氧磷酶1(PON1)及氧化低密度脂蛋白(ox-LDL)变化的关系。方法:对青海省玉树县结古镇(城镇地区,平均海拔3 700m)和隆宝镇(纯牧业地区,平均海拔4 800m)176例藏族人群进行脂代谢的特点及与PON1、ox-LDL的关系进行研究分析。结果:1玉树地区高脂血症患病率为46.0%(81/176例),其中结古镇组高脂血症的患病率为60.2%(71/118例),显著高于隆宝镇组17.2%(10/58例);结古镇组高TC血症、高TG血症、高LDL血症的患病率分别为44.9%、25.4%和47.5%,显著高于隆宝镇组19.0%、5.2%和17.2%),P<0.01;2相关分析显示PON1与TC、TG呈负相关,ox-LDL与海拔及Hb呈正相关,P<0.01;3Logistic回归分析显示,影响脂质代谢的主要因素为年龄、住址(结古镇和隆宝镇)、Hb及腹围。结论:不同海拔不同生活环境藏族血脂水平与PON1及ox-LDL浓度不同,血脂增高是血浆PON1降低原因之一,海拔的差异性、城镇化生活环境、高龄及血红蛋白可能是高原地区藏族PON1及ox-LDL水平不同的一个影响因素。
Objective: To explore the characteristics of blood lipid metabolism and the relationship with PON1 and ox-LDL in Tibetan people under different living environments in the plateau. Methods: The characteristics of lipid metabolism in 176 cases of Tibetan population in Jiegu town of Yushu county of Qinghai province (average of 3 700m in urban area and Longbao town (pure livestock husbandry area) with an average elevation of 4 800m) were compared with those of PON1, ox-LDL Relationship research and analysis. Results: The prevalence of hyperlipidemia in Yushu district was 46.0% (81/176 cases). The prevalence of hyperlipidemia in Jiegu town group was 60.2% (71/118 cases), which was significantly higher than that of Longbao town Group 17.2% (10/58 cases). The prevalences of hypercholesteremia, hypercholesterolemia and hyperlipidemia in Jiegu town group were 44.9%, 25.4% and 47.5%, respectively, which were significantly higher than those in Longbao town group 19.0 %, 5.2% and 17.2% respectively), P <0.01; 2 Correlation analysis showed that there was a negative correlation between PON1 and TC and TG, ox-LDL and altitude and Hb were positively correlated, P <0.01; 3Logistic regression analysis showed that the effects of lipid metabolism The main factors are age, address (Jie Guzhen and Longbao town), Hb and abdominal circumference. CONCLUSIONS: Tibetan blood lipid levels differ from those of PON1 and ox-LDL at different altitudes in different living environments. Increased blood lipids is one of the reasons for the decrease of plasma PON1. The differences in altitude, urban living environment, elderly and hemoglobin may be the result of PON1 and ox -LDL level of a different factor.