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本文应用生物反应调节剂之一胸腺肽治疗更年期症状,共观察38例治疗前、后Kupperman Score(简称K分)和15例治疗前后T细胞亚群的分布。结果示洽疗前后K分值分别为25.58±6.15和9.52±3.43,经统计分析二者之间有非常显著差异(P<0.001),表明胸腺肽有缓解更年期症状的作用。更年期症状组T细胞亚群的分布为CD_3 78.34％、CD_4 43.11％、CD_8 36.40％和CD_4/CD_8 1.18,与正常对照组(4例)比较,表明更年期症状组有免疫功能紊乱,以CD_8细胞的上升占优势。应用胸腺肽1～2月后,T细胞亚群的分布为CD_3 73.60％、CD_4 46.32％、CD_8 27.76％和CD_4/CD_8 1.68,表明胸腺肽可纠正这种不平衡状态,使抑制了的免疫功能得到恢复。胸腺肽-免疫-内分泌系统之间的调节是临床治疗更年期症状的依据,很有实用价值,有待深入研究。
Thymopeptide, one of the biological response modifiers, was used in the treatment of menopausal symptoms. The distribution of 38 Kupperman Score (K score) and 15 T cell subsets before and after treatment were observed in 38 patients before and after treatment. The results showed that K scores before and after treatment were 25.58 ± 6.15 and 9.52 ± 3.43, respectively. There was a significant difference between the two groups (P <0.001), indicating that thymosin can relieve menopausal symptoms. The distribution of T cell subsets in climacteric group was 78.34% for CD_3, 43.11% for CD_4, 36.40% for CD_4 and 1.18 for CD_4 / CD_8, compared with the normal control group (4 cases), indicating that immune dysfunction was found in the menopausal symptoms group, Rise prevails. Thymosin 1 to 2 months after application, the distribution of T cell subsets was 73.60% for CD_3, 46.32% for CD_4, 27.76% for CD_8 and 1.68 for CD_4 / CD_8, indicating that thymosin can correct this imbalance and restore the suppressed immune function . Regulation of thymosin - immune - endocrine system is the basis for clinical treatment of menopausal symptoms, very practical value, pending further study.