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研究小儿性白血病血清NO_2／NO_3和cGMP的变化及其临床意义，为本文研究目的。应用镀铜镉还原法和放射免疫法检测患儿血清中NO的代谢产物NO_2／NO_3和cGMP含量。结果表明：小儿急性白血病急性期血清NO_2／NO_3和cGMP的含量明显高于正常对照组和完全缓解期组（P＜0．01）；急性淋巴细胞白血病与急性非淋巴细胞白血病相比无显著性差异（P＞0．05）。完全缓解期组与正常对照组相比，无显著性差异（P＞0．05）。结论：血清NO的检测可用于判断小儿急性白血的病情和监测化疗效果的指标之一，揭示了临床选用NO的细胞毒性作用可能为小儿急性白血病的治疗提供新的方法。
To study the changes of serum NO 2 / NO 3 and cGMP in children with leukemia and its clinical significance is the purpose of this study. Copper-cadmium reduction method and radioimmunoassay were used to detect the contents of NO 2 / NO 3 and cGMP in serum of children with NO. The results showed that the serum levels of NO 2 / NO 3 and cGMP in children acute leukemia at acute stage were significantly higher than those in normal control group and complete remission stage (P <0.01); there was no significant difference between acute lymphoblastic leukemia and acute non-lymphocytic leukemia Difference (P> 0.05). The complete remission group compared with the normal control group, no significant difference (P> 0.05). Conclusion: The detection of serum NO can be used to judge the condition of acute leukemia in children and to monitor the effect of chemotherapy. It indicates that the cytotoxicity of NO in clinical use may provide a new method for the treatment of childhood acute leukemia.