放疗和化疗目前仍是治疗恶性肿瘤的重要手段 ,但是 ,由于放化疗难以区分正常的与恶性的肿瘤细胞 ,因此 ,与肿瘤治疗相关的副作用不仅限制了治疗的强度 ,降低治疗的疗效 ,也影响患者的生活质量 ,甚至危及生命。提高治疗指数的方法包括提高肿瘤细胞相对于正常组织的敏感性 ,或在? Radiotherapy and chemotherapy are still important methods for the treatment of malignant tumors. However, because radiotherapy and chemotherapy are difficult to differentiate between normal and malignant tumor cells, the side effects associated with tumor treatment not only limit the intensity of treatment but also reduce the therapeutic effect of treatment, and also affect The quality of life of patients, and even life-threatening. Methods to increase the therapeutic index include increasing the sensitivity of tumor cells relative to normal tissue,