结核分枝杆菌感染后是否患病,是受环境和宿主遗传因子的影响。维生索D缺乏可增加对结核病的敏感性,维生素D能激活巨噬细胞,抑制细胞内结核杆菌的生长。维生素D对结核病的抑制作用也受维生素D受体(VDR)多态性的影响。作者为了证实血清维生素D浓度和VDR多态体对结核病的易感性的影响,对结核病发病率较高的,生活在英国的亚州古吉拉特人进行调查。 方法和对象 被调查者都是从英国哈罗市某医院筛选出的居住在伦敦的具有古吉拉特人血统的移民,他们以素食 Mycobacterium tuberculosis infection is ill, is affected by environmental and host genetic factors. Vitamin D deficiency can increase the sensitivity of tuberculosis, vitamin D can activate macrophages, inhibit the growth of intracellular Mycobacterium tuberculosis. The inhibitory effect of vitamin D on tuberculosis is also affected by the vitamin D receptor (VDR) polymorphism. To investigate the impact of serum vitamin D levels and VDR polymorphisms on the susceptibility to tuberculosis, the authors investigated the Gujarat of Asia, which has a high prevalence of tuberculosis, living in the UK. Methods and Subjects The respondents were all immigrants living in London who were screened from a hospital in the city of Harrow in the United Kingdom and have Gujrat origin,