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目的:探讨MMP-2、E-cadherin在喉癌组织中的表达及其与喉癌颈部淋巴结转移之间的关系。方法:应用免疫组织化学SP法检测10例正常喉黏膜和48例原发性声门上喉癌组织中MMP-2和E-cadherin的表达。结果:MMP-2在声门上喉癌组织中的表达明显高于正常喉黏膜组织中的表达;淋巴结转移组明显高于无淋巴结转移组(P<0.05);E-cadherin在正常喉黏膜组织中的表达明显高于在声门上喉癌组织中的表达;在淋巴结转移组明显低于无淋巴结转移组(P<0.05)。MMP-2和E-cadherin在声门上喉癌组织中的表达呈负相关(r=-0.41)。分别用MMP-2(+)、E-cadherin(-)及MMP-2(+)与E-cadherin(-)联合来预测喉癌颈部淋巴结转移,MMP-2(+)的敏感性最高(91.7%),特异性(58.3%)和阳性预测值(68.8%)最低。MMP-2(+)与E-cadherin(-)联合的敏感性最低(79.2%),特异性(95.8%)和阳性预测值(95.0%)最高。E-cadherin(-)的各项指标介于两者之间。结论:MMP-2和E-cadherin蛋白的表达可以作为判断声门上喉癌淋巴结转移的有效指标,联合应用MMP-2和E-cadherin蛋白的检测能够提高判断声门上喉癌淋巴结转移的准确率,对于声门上喉癌的手术治疗具有指导意义。
Objective: To investigate the expression of MMP-2 and E-cadherin in laryngeal carcinoma and their relationship with cervical lymph node metastasis of laryngeal carcinoma. Methods: The expressions of MMP-2 and E-cadherin in 10 cases of normal laryngeal mucosa and 48 cases of primary supraglottic laryngeal carcinoma were detected by immunohistochemical SP method. Results: The expression of MMP-2 in supraglottic laryngeal carcinoma was significantly higher than that in normal laryngeal mucosa; the lymph node metastasis was significantly higher than that in non-lymph node metastasis (P <0.05); the expression of E-cadherin in normal laryngeal mucosa (P <0.05), which was significantly higher than that in the supraglottic carcinoma (P <0.05). It was significantly lower in lymph node metastasis than in those without lymph node metastasis (P <0.05). The expression of MMP-2 and E-cadherin in supraglottic laryngeal carcinoma was negatively correlated (r = -0.41). MMP-2 (+), E-cadherin (-) and MMP-2 (+) and E-cadherin (-) were combined to predict cervical lymph node metastasis of laryngeal carcinoma, 91.7%), specificity (58.3%) and positive predictive value (68.8%). The lowest sensitivity (79.2%), specificity (95.8%) and positive predictive value (95.0%) of MMP-2 (+) and E-cadherin (-) were the highest. E-cadherin (-) of the indicators in between. Conclusions: The expressions of MMP-2 and E-cadherin may be useful indicators for the evaluation of lymph node metastasis in supraglottic carcinoma. The combination of MMP-2 and E-cadherin could improve the accuracy of lymph node metastasis in supraglottic carcinoma Rate, for the treatment of supraglottic laryngeal cancer has guiding significance.