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目的探讨甲状腺功能亢进症(简称甲亢)患者治疗前后抗中性粒细胞胞浆抗体(ANCA)检出情况及其与短期抗甲状腺药物治疗的关系。方法将60例初诊Graves病甲亢患者治疗前作为未治疗组(n=60),治疗后归为治疗组(n=10),40例非甲亢健康人群作为对照组(n=40)。用间接免疫荧光法(IIF)检测血清ANCA及抗核抗体(ANA)。结果 2例初诊未治疗甲亢患者ANCA-IIF阳性,10例治疗前ANCA阴性患者药物治疗6个月后及健康人群未检测出ANCA,患者与健康人群差异无统计学意义(P>0.05)。所有血清ANA均阴性。结论 ANCA与Graves病本身可能无关,以及短期抗甲状腺药物治疗可能不诱发ANCA。
Objective To investigate the detection of anti-neutrophil cytoplasmic antibody (ANCA) before and after treatment in patients with hyperthyroidism (hyperthyroidism) and its relationship with short-term anti-thyroid drug therapy. Methods Sixty patients with newly diagnosed hyperthyroidism with Graves’ disease were treated as untreated group (n = 60) and treated as treatment group (n = 10). Forty non-hyperthyroid patients as control group (n = 40). Serum ANCA and antinuclear antibody (ANA) were detected by indirect immunofluorescence (IIF). Results ANCA-IIF was positive in 2 newly diagnosed patients with untreated hyperthyroidism. ANCA-IIF was positive in 10 patients with ANCA-negative before treatment and no ANCA was detected in healthy people. There was no significant difference between the two groups (P> 0.05). All serum ANA was negative. Conclusion ANCA may not be related to Graves disease itself, and short-term anti-thyroid drug therapy may not induce ANCA.