论文部分内容阅读
前药(prodrug)是一类经过生物体内转化后才具有药理作用的化合物。与传统纳米药物输送系统相比具有载药率确定、稳定性高、爆释现象小等优点。但是,前药本身也面临着可控性,特异性释药不足而引起效果不佳等问题。因此,能够靶向病灶部位并能够针对病灶部位进行特异性释药的刺激敏感型前药受到广泛研究。本文以国内外学者及本课题组的研究成果为基础,以肿瘤部位特殊的生理环境为背景,综述了近年来pH敏感、温敏、氧化还原敏感、酶敏感等生物刺激响应型抗肿瘤聚合物前药的研究进展。
Prodrugs are a group of compounds that undergo pharmacological effects after being transformed in vivo. Compared with the traditional nano-drug delivery system with drug loading rate, high stability, small explosion and other advantages. However, the prodrug itself is also faced with the problem of controllability, lack of specific drug release and poor efficacy. Therefore, stimuli-sensitive prodrugs that can target the lesion site and specifically target the lesion site have been extensively studied. Based on the domestic and foreign scholars and the research results of our group, taking the special physiological environment of the tumor as the background, the biostimulation-responsive antitumor polymers such as pH-sensitive, temperature-sensitive, redox- Research Progress of Prodrugs.