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以磺化β－ＣＤ作为手性分离添加剂，分别对萘普生和萘普生甲酯进行了手性分离研究，当磺化β－ＣＤ的浓度为３．５％（Ｗ／Ｖ）时，萘普生和萘普生甲酯的手性分离度都可大于２，但萘普生与萘普生甲酯不能达到同时拆分。如果同时以磺化β－ＣＤ和ＨＰ－β－ＣＤ作为手性分离添加剂，则可对萘普生和萘普生甲酯达到同时拆分，当磺化β－ＣＤ和ＨＰ－β－ＣＤ的浓度分别为３．５％和１．５％（Ｗ／Ｖ）时，对萘磺生和萘普生甲酯两种消旋体的手性分离度分别为２．０７和３．６８。
The chiral separation of naproxen and naproxen was studied with sulfonated β-CD as a chiral separation additive. When the concentration of sulfonated β-CD was 3.5% (W / V) Naproxen and naproxen methyl chiral separation can be greater than 2, but naproxen and naproxen methyl can not be resolved at the same time. If both sulphonated β-CD and HP-β-CD are used as chiral separation additives, simultaneous resolution of naproxen and naproxen can be achieved. When sulfonated β-CD and HP-β-CD At the concentrations of 3.5% and 1.5% (W / V), respectively, the chiral separations of the two racemates of naphthalene sulfonamide and naproxen were 2.07 and 3.68, respectively.