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目的:研究中晚孕期18-三体综合征胎儿超声影像的变化。方法:回顾分析经羊膜腔穿刺、脐血管穿刺胎儿染色体分析确诊为18-三体的胎儿24例的临床资料和超声影像特征。结果:24例18-三体胎儿中,22例超声影像有变化,占全部病例的91.7%;最常见的超声变化是心脏畸形,共15例,占62.5%;其它常见的异常有脉络膜囊肿、脐带异常、肢体异常、宫内生长迟缓、脑室扩大、小脑延髓池扩大等;还可见颅骨变形、颜面裂、颈项皮肤增厚、消化道闭锁、腹壁缺损、膈疝、肾盂轻度积水、羊水过多等。结论:超过90%的18-三体胎儿中晚孕期可发现超声影像改变,中晚孕期胎儿超声检查是产前筛查18-三体胎儿的有效手段。
Objective: To study the changes of fetal ultrasound image of 18-trisomy in middle and late pregnancy. Methods: A retrospective analysis of the amniocentesis, umbilical cord puncture fetal chromosome analysis confirmed 18 cases of fetal trisomy 18 cases of clinical data and ultrasound imaging features. Results: In 24 cases of 18-trisomy fetus, 22 cases had changes of ultrasound images, accounting for 91.7% of all cases. The most common changes were heart abnormalities, 15 cases (62.5%). Other common abnormalities were choroid cyst, Umbilical cord abnormalities, abnormal limbs, intrauterine growth retardation, enlarged ventricles, cerebellar bulbar cistern expansion; also visible skull deformation, facial cleft, neck skin thickening, gastrointestinal atresia, abdominal defect, diaphragmatic hernia, mild hydronephrosis, amniotic fluid too More wait. CONCLUSIONS: Over 90% of 18- trisomy fetuses can be found to have altered ultrasound images in their second and third trimester fetuses. Fetal sonography in the second and third trimester of pregnancy is an effective measure for prenatal screening of 18-trisomy fetuses.