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目的:探讨慢性胆囊炎患者血清瘦素(Lep)、可溶性瘦素受体(s LR)与血脂水平的变化及其相互关系。方法:选择103例慢性胆囊炎患者,以91例健康体检者为对照,测定所有受试者空腹血清Lep、s LR、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL),分析慢性胆囊炎患者血清Lep、s LR水平与血脂水平的关系。结果:与对照组比较,慢性胆囊炎组患者血清TC、LDL和Lep水平均明显升高,而s LR水平明显降低(均P<0.05)。单因素分析显示,Lep水平与TC、TG和HDL水平呈明显正相关(均P<0.05),而s LR水平与各血脂指标无明显相关性(均P>0.05);多元回归分析显示,Lep水平与TC水平呈明显正相关(P<0.05)。结论:慢性胆囊炎患者血清Lep明显升高、s LR水平降低以及血脂代谢紊乱,其中,Lep升高所致胆固醇代谢障碍可能是主要原因。
Objective: To investigate the changes of serum leptin (Lep), soluble leptin receptor (s LR) and serum lipids in patients with chronic cholecystitis and their correlations. Methods: A total of 103 patients with chronic cholecystitis were enrolled in this study. 91 healthy subjects were selected as control group. Fasting serum Lep, s LR, total cholesterol (TC), triglyceride (TG), low density lipoprotein ), High-density lipoprotein (HDL) in patients with chronic cholecystitis serum Lep, s LR levels and the relationship between blood lipid levels. Results: Compared with the control group, serum TC, LDL and Lep levels in patients with chronic cholecystitis were significantly increased, while s LR levels were significantly lower (all P <0.05). Univariate analysis showed that there was a significant positive correlation between Lep level and TC, TG and HDL levels (all P <0.05), while there was no significant correlation between s LR level and lipid profile (all P> 0.05). Multiple regression analysis showed that Lep There was a positive correlation between the level of TC and TC (P <0.05). Conclusion: Serum Lep is significantly elevated in patients with chronic cholecystitis, s LR levels decreased and dyslipidemia, of which, Lep elevated cholesterol metabolism may be the main reason.