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本实验观察了小鼠感染旋毛虫后不同时期其肠壁组织、肝脏以及血清中ＸＯＤ、ＭＤＡ和ＧＳＨ的改变，以期了解氧自由基、氧化代谢产物以及抗氧化能力在旋毛虫病的发生、发展过程中所起的作用，揭示旋毛虫病产生的生理机制。结果显示：小鼠在感染旋毛虫后的第３～７ｄ，肠壁组织中的ＭＤＡ明显升高（Ｐ＜０．０１），ＧＳＨ相应明显降低（Ｐ＜０．０１）。１４ｄ后ＧＳＨ逐渐恢复，ＭＤＡ在下降之后于３０ｄ时再度升高。肝组织中的ＸＯＤ、ＭＤＡ在感染后３～７ｄ即出现明显的升高（Ｐ＜０．０１），ＧＳＨ明显降低（Ｐ＜０．０１）。１４ｄ后，ＸＯＤ恢复正常，而ＭＤＡ和ＧＳＨ继续上升并维持较高的水平。血液作为新陈代谢的重要场所ＭＤＡ在感染后一直维持较高的水平。实验表明：氧自由基、氧化代谢产物以及抗氧化能力的改变在旋毛虫病的发生、发展过程中起着重要的作用。提示检测氧自由基是了解旋毛虫病的病变程度及监测病变发展的一项重要的指标。
In this study, the changes of XOD, MDA and GSH in the intestinal wall tissue, liver and serum of mice infected with Trichinella at different periods were observed in order to know the occurrence and development of the oxygen free radicals, oxidative metabolites and antioxidant capacity in Trichinella spiralis The role of the process, revealing the physiological mechanism of Trichinellosis. The results showed that the MDA content in the intestinal wall was significantly increased (P <0.01) and the GSH was significantly reduced on the 3rd ~ 7th day after infection with Trichinella in mice (P <0.01). GSH gradually recovered after 14 days, MDA increased again after 30 days. XOD and MDA in liver tissue were significantly increased from 3 to 7 days after infection (P <0.01), GSH was significantly decreased (P <0.01). After 14 days, XOD returned to normal, while MDA and GSH continued to rise and maintain a high level. MDA, an important site of metabolism, has been maintained at a high level after infection. Experiments show that: oxygen free radicals, oxidative metabolites and antioxidant capacity changes in the occurrence and development of trichinosis plays an important role. Tip detection of oxygen free radicals is to understand the degree of pathological changes of trichinellosis and monitor the development of lesions is an important indicator.