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目的:探讨不同剂型雌激素在激素替代治疗(HRT)中的症状改善程度及不良反应,比较各型药物疗效。方法:回顾分析自2009年5月～2010年10月该院门诊就诊的更年期妇女HRT治疗中根据其意愿,分别予口服雌激素、阴道给雌激素及经皮吸收雌激素共76例HRT治疗。用药前详细了解病史,综合分析患者受雌激素影响的程度、绝经的时间、体检、妇检情况,掌握基本健康状况及子宫内膜、乳腺、肝功能、肾功能、血糖、血脂等,选择针对个体的用药分析、用药前后疗效及用药后不良反应。结果:口服雌激素、阴道给雌激素及经皮吸收雌激素服用后症状改善程度有明显差异;不同剂型雌激素在症状改善及不良反应有差异。结论:根据患者不同的特点,选用不同吸收途径的雌激素能有效地改善症状,预防不良反应的发生,以便及时调整剂量、剂型或方案,争取最好效果,提高患者对激素替代治疗的依从性。
OBJECTIVE: To investigate the improvement of symptoms and adverse reactions of different dosage forms of estrogen in hormone replacement therapy (HRT) and compare the curative effects of different types of drugs. Methods: Retrospective analysis from May 2009 to October 2010 outpatient clinics in menopause women HRT treatment according to their wishes, respectively, oral estrogen, vaginal estrogen and percutaneous estrogen absorption of 76 cases of HRT treatment. A detailed history of medication before treatment, a comprehensive analysis of patients affected by the degree of estrogen, menopause, physical examination, the situation of women, to grasp the basic health and endometrial, breast, liver function, renal function, blood glucose, blood lipids, Analysis of individual medication, before and after treatment efficacy and adverse reactions after treatment. Results: There was a significant difference in the improvement of symptoms between oral administration of estrogen and vaginal estrogen and percutaneous absorption of estrogen. Differences of symptoms and side effects of different dosage forms of estrogen were observed. Conclusion: According to different characteristics of patients, the selection of different absorption routes of estrogen can effectively improve the symptoms and prevent the occurrence of adverse reactions in order to timely adjust the dose, dosage form or program for the best results and improve patient compliance with hormone replacement therapy .