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目的:探讨急性冠脉综合征患者糖化血红蛋白水平对预后的影响。方法:选取随访的ACS患者94例纳入本研究。根据Hb Alc检测结果,将患者分为A组、B组、C组。观察患者VLDL、CRP、BMI、EF水平变化情况、心血管事件发生情况,分析Hb Alc水平和各个变量之间的相关性。结果:A组随访3个月时VLDL、CRP水平低于入院时,EF水平高于入院时,差异有统计学意义(P<0.05);B组、C组随访3个月时VLDL、CRP水平低于入院时,差异有统计学意义(P<0.05);A组、B组随访12个月时VLDL水平低于入院时,EF水平高于入院时,差异有统计学意义(P<0.05);C组随访12个月时VLDL水平低于入院时,差异有统计学意义(P<0.05)。B组严重心律失常、急性心衰发生率高于A组,差异有统计学意义(P<0.05);C组心绞痛、严重心律失常、再发心肌梗死、急性心衰、其他发生率高于A组,差异有统计学意义(P<0.05);C组心绞痛、再发心肌梗死、急性心衰、其他发生率高于B组,差异有统计学意义(P<0.05)。结论:急性冠脉综合征患者糖化血红蛋白水平变化情况可预测疾病发展情况,可辅助临床诊治。
Objective: To investigate the effect of glycosylated hemoglobin (HbA1c) on prognosis in patients with acute coronary syndrome. Methods: Ninety-four ACS patients were included in this study. According to Hb Alc test results, the patients were divided into A, B, C group. The changes of VLDL, CRP, BMI and EF were observed. The occurrence of cardiovascular events and the correlation between Hb Alc levels and various variables were analyzed. Results: The levels of VLDL and CRP in group A at 3 months follow-up were lower than those at admission and EF were higher than those at admission (P <0.05). The levels of VLDL and CRP (P <0.05). The level of VLDL in group A and group B at 12 months of follow-up was lower than that at admission, and the level of EF was higher than that at admission (P <0.05) ; The VLDL level in C group was lower than that at admission at 12 months of follow-up (P <0.05). The incidence of severe arrhythmia and acute heart failure in group B was significantly higher than that in group A (P <0.05). The incidences of angina pectoris, severe arrhythmia, recurrent myocardial infarction and acute heart failure in group C were higher than those in group A (P <0.05). The incidences of angina pectoris, recurrent myocardial infarction and acute heart failure in group C were higher than those in group B (P <0.05). Conclusion: The changes of glycosylated hemoglobin in patients with acute coronary syndrome can predict the development of the disease, which may be helpful to clinical diagnosis and treatment.