肿瘤病人再发第二个肿瘤甚或多发性肿瘤的机会并不少见,1961年Moertel已统计到1万例多发性原发肿瘤病例,其中再发第二个原发肿瘤的发生率达51%.作者注意到黑色素瘤病人再发淋巴瘤的机会颇高,为此分析1986～1991年Yale-New Haven医院收治的664例黑色素瘤病例,计男性352例,女性312例,其平均年龄分别为55岁和59岁(12～93岁),在确诊后26个月内死亡115例(17%) ,另56例带癌存活.黑色素瘤的部位计躯干39%、下肢25%、上肢19%和头颈部11%,其厚度<0.75mm占31%,0.76～3mm占51%.在此664例黑色素瘤病人中,54例(8.1%)有其他恶性肿瘤,计1个50例,3个4例.黑色素瘤病灶属T_1期占30%,T_2期(0.76～1.5mm)18%,T_3期35%,T_4期(>3mm)17%.病变浸润越深,多发性恶性肿瘤的机会越多,在T_1、T_2、T_3和T_4病灶中再发第二个恶性肿瘤的病例分别占7.9%、5.6%、12.4%和13.4%.再发第二个肿瘤病人的年龄高于全组(62.5:57岁),男女相等(29:25).将肿瘤发生的次序分为两组:第一组23例,即先发生黑色素瘤,平均相隔17月发生第二个肿瘤,平均年龄65.1岁,男女之比为14:9,7例已死亡,6例已带癌生存41个月,无病生存率43%(全组为73%);第二组31例,即先有其他恶性肿瘤,平均相隔61个月再发生黑色素瘤,平均年龄60.5岁,男女之比为15:16.5例已死亡,8例带癌? It is not uncommon for cancer patients to have a second tumor or multiple tumors. In 1961, Moertel had already counted 10,000 cases of multiple primary tumors, among which the incidence of recurrence of a second primary tumor was 51%. The authors noted that melanoma patients have a high chance of recurrence of lymphoma. This study analyzed 664 cases of melanoma treated in Yale-New Haven Hospital from 1986 to 1991, including 352 males and 312 females, with an average age of 55. At the age of 59 and 59 (12 to 93 years), 115 (17%) patients died within 26 months after diagnosis, and another 56 patients had cancer. The melanoma site included 39% of the trunk, 25% of the lower extremities, and 19% of the upper extremities. 11% of the head and neck, its thickness <0.75mm accounted for 31%, 0.76 ~ 3mm accounted for 51%. Of the 664 cases of melanoma patients, 54 (8.1%) had other malignant tumors, including 1 50 cases, 3 In 4 cases, melanoma lesions accounted for 30% in T 1 stage, 18% in T 2 stage (0.76-1.5mm), 35% in T 3 stage, and 17% in T 4 stage (>3mm). The deeper the lesions were, the more chances of multiple malignant tumors were. Most of the patients who relapsed with the second malignant tumor in T_1, T_2, T_3, and T_4 lesions accounted for 7.9%, 5.6%, 12.4%, and 13.4%, respectively. The second tumor patient was older than the entire group (62.5). 57 years old, male and female equal (29: 25). The order of tumors is divided into two groups: the first group of 23 cases, the first occurrence of melanoma, the average occurred in 17 months apart from the second tumor, the average age of 65.1 years, male to female ratio of 14:9, 7 cases It was dead, 6 cases had survived with cancer for 41 months, disease-free survival rate was 43% (73% in the whole group), and the second group was 31 cases, that is, there were other malignant tumors first, with melanoma relapsed after an average of 61 months. The average age was 60.5 years. The ratio of male to female was 15:16.5 cases dead. Eight cases had cancer?