论文部分内容阅读
目的分析苏州地区早产孕妇与足月妊娠孕妇早孕期血清25羟维生素D[25-hydroxy vitamin D,25(OH)D]水平差异,为妊娠期补充维生素D,及是否可成为针对早产的潜在预防策略作前期研究工作。方法选择2013年1月份在南京医科大学附属苏州医院产科门诊进行产前保健的孕妇,分为足月妊娠组及早产组,取妊娠13-16w孕妇血清,排除慢性肝病、甲状腺功能亢进和结缔组织疾病者。采用酶联免疫吸附法测定血清25(OH)D水平,在终止妊娠时采取生殖道分泌物行细菌培养,采用t检验比较足月妊娠组及早产组25(OH)D水平及生殖道感染率。结果早产组25(OH)D(12.02±8.59)nmol/L,明显低于足月妊娠组(27.46±3.61)nmol/L;早产组生殖道感染率(57%)明显高于足月妊娠组(21%),两组比较差异有显著性意义。结论苏州地区孕妇维生素D水平普遍不足,早产组较对照组维生素D水平更低,孕妇应该根据自身情况额外补充维生素D制剂。
Objective To analyze the difference of serum 25-hydroxy vitamin D (25 (OH) D] level between premature pregnant women and full-term pregnant women in Suzhou during pregnancy and to provide vitamin D for pregnancy and whether it could be a potential preventive measure against premature labor Strategy for pre-research work. Methods Pregnant women who took prenatal care at the outpatient department of Obstetrics and Gynecology, Suzhou Hospital affiliated to Nanjing Medical University in January 2013 were divided into full-term pregnancy group and preterm birth group. Pregnant women of 13-16 weeks of pregnancy were excluded from the study. Chronic liver disease, hyperthyroidism and connective tissue Disease. Serum 25 (OH) D levels were measured by enzyme-linked immunosorbent assay (ELISA), bacterial cultures of genital tract secretions were taken at termination of pregnancy, t-test was used to compare 25 (OH) D levels and genital tract infection rate in term pregnancy group and preterm birth group . Results The 25 (OH) D (12.02 ± 8.59) nmol / L in preterm labor group was significantly lower than that of term pregnancy group (27.46 ± 3.61) nmol / L, and the prevalence of genital tract infection in preterm labor group was significantly higher than that of term pregnancy group (21%), the difference between the two groups was significant. Conclusion The level of vitamin D in pregnant women in Suzhou area is generally inadequate. The vitamin D level in preterm birth group is lower than that in control group. Pregnant women should be supplemented with vitamin D according to their own circumstances.