正常情况下,通过丘脑—垂体—甲状腺轴的调节,机体保持内外环境碘代谢的平衡。外环境的改变以及丘脑—垂体—甲状腺轴和肾功能的改变等因素,均可导致机体碘代谢的紊乱。地方性高碘甲状腺肿(以下简称高碘病)是机体从外环境中摄入过量碘所致的一种地方病,病区居民普遍受到外环境高碘因素的影响,均有不同程度的碘代谢紊乱。同时有报道认为,高碘病患者存在有免疫功能的改变。本文通过调查分析,报告高碘病病区居民的碘代谢特征和甲状腺自身抗体的测定结果。 Under normal circumstances, through the regulation of the thalamus - pituitary - thyroid axis, the body maintains the balance of iodine metabolism inside and outside the environment. Changes in the external environment and changes in the thalamus - pituitary - thyroid axis and renal function and other factors, can lead to the disorder of iodine metabolism. Local high iodine goiter (hereinafter referred to as high iodine disease) is the body caused by excessive intake of iodine from the external environment caused by a endemic disease residents generally affected by the external environment, the impact of high iodine, have varying degrees of iodine metabolism disorder. At the same time there are reports that there is a change in immune function in patients with iodine deficiency disorders. In this paper, Iodine metabolism and thyroid autoantibodies in residents with high incidence of iodine deficiency disease were reported through investigation and analysis.