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研究目的:中风的发生对冰片药代动力学特征的影响。创新要点:首次对冰片及其中药制剂在脑取血再灌注(中风病理状态下)的药代动力学进行研究,为药物在中风治疗中的应用提供参考。研究方法:采用大脑中动脉堵塞法建立脑缺血中风模型,中风组和假手术组分别灌胃冰片与醒脑静口服制剂,不同时间点眼眶取血后用气相色谱氢火焰离子化检测器(GC-FID)测定,并用非房室模型分析药时曲线(见图3),得各药代动力学参数(见表2)。重要结论:脑取血再灌注损伤(中风状态)可以促进冰片的吸收及生物利用,醒脑静中其他成分对其药代动力学特征也有一定影响。
Purpose: The impact of stroke on the pharmacokinetics of borneol. Innovative points: For the first time, the pharmacokinetics of borneol and its traditional Chinese medicine in the cerebral blood reperfusion (stroke pathology) study for the drug in the treatment of stroke provide a reference. Methods: The middle cerebral artery occlusion method was used to establish the cerebral ischemic stroke model. The stroke group and the sham operation group were respectively treated with borneol and xingnaojing oral preparations. Blood was collected from orbital orbit at different time points and analyzed by gas chromatography hydrogen flame ionization detector GC-FID), and pharmacokinetic parameters were analyzed using a non-compartmental model (see Figure 3) (see Table 2). Important conclusion: Cerebral blood reperfusion injury (stroke status) can promote the absorption and bioavailability of borneol, while other components in Xingjingjing also have certain influence on its pharmacokinetic characteristics.