由于凝血生理学的迅速发展,不但对凝血因子有进一步的认识,而且对循环抗凝物质的性质也有一定程度的了解。Cooke 等提到由于循环抗凝物质而引起的出血性病例,其中包括抗Ⅰ、Ⅴ、Ⅶ、Ⅷ、Ⅸ、Ⅺ和Ⅻ等因子。文献中所报道的此类病例多数是抗 Due to the rapid development of coagulation physiology, not only further understanding of clotting factors, but also a certain degree of understanding of the nature of circulating anticoagulant substances. Cooke et al. Mentioned hemorrhagic cases caused by circulating anticoagulant substances, including anti-Ⅰ, Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅺ and Ⅻ and other factors. Most of the reported cases in the literature are resistant