子痫前期(PE)是妊娠期特有疾病,严重威胁孕产妇、胎婴儿的健康和生存质量。PE的病因及发病机制可能与遗传、免疫、氧化应激、胎盘缺血缺氧、血管内皮功能紊乱等因素相关,但尚未完全阐明。因此,及早预测、诊断及预防PE至关重要,可明显改善孕产妇妊娠结局及胎婴儿的预后。本文现将可帮助预测PE有价值的生物标记物做一综述。 Pre-eclampsia (PE) is a peculiar disease during pregnancy, which seriously threatens the health and quality of life of pregnant women and fetus. Etiology and pathogenesis of PE may be related to genetic, immune, oxidative stress, placental ischemia and hypoxia, vascular endothelial dysfunction and other factors, but not yet fully elucidated. Therefore, the early prediction, diagnosis and prevention of PE is essential, can significantly improve maternal pregnancy outcomes and fetal baby prognosis. This article will now give an overview of the valuable biomarkers that predict PE.