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目的评价体腔持续热灌注化疗在恶性胸腹水治疗中的应用疗效,探讨其临床适用性。方法选择2011年3月至2013年3月间收治的62例恶性肿瘤伴恶性胸腹水患者,随机分为观察组(32例)和对照组(30例)。对照组患者采用单纯腔内化疗,于腔内中心静脉置管抽液后注入化疗药物;观察组患者采用体腔持续热灌注化疗,于腔内置管抽液化疗联合体腔持续热灌注。观察两组患者的治疗有效率、Karnofsky评分及不良反应情况。结果两组患者治疗后症状均有所缓解,观察组患者的治疗有效率为93.8%,对照组患者为70.0%,两组比较差异有统计学意义(X2=5.98,P<0.05)。Karnofsky评分改善情况比较,两组差异有统计学意义(X2=4.22,P<0.05)。两组患者不良反应发生率比较,差异有统计学意义(X2=10.91,P<0.05)。结论体腔持续热灌注化疗在恶性胸腹水治疗中有很好的疗效,适合临床长期推广应用。
Objective To evaluate the curative effect of continuous thermal perfusion chemotherapy of body cavity in the treatment of malignant pleural effusion and to discuss its clinical applicability. Methods Sixty-two patients with malignant pleural effusion and malignant pleural effusion admitted from March 2011 to March 2013 were randomly divided into observation group (32 cases) and control group (30 cases). Patients in the control group were treated with simple intracavitary chemotherapy, and chemotherapy drugs were injected into the central venous catheter after catheterization. The patients in the observation group were treated with continuous thermal perfusion chemotherapy in the body cavity and continuous intra-lumen infusion with chemotherapy in the cavity. The treatment efficiency, Karnofsky score and adverse reactions of the two groups were observed. Results The symptoms of both groups were relieved after treatment. The effective rate was 93.8% in the observation group and 70.0% in the control group. There was significant difference between the two groups (X2 = 5.98, P <0.05). Karnofsky score improved compared with the two groups was statistically significant difference (X2 = 4.22, P <0.05). Adverse reactions between the two groups, the difference was statistically significant (X2 = 10.91, P <0.05). Conclusion Continuous intraluminal hyperthermic chemotherapy has good efficacy in the treatment of malignant pleural effusion and ascites, which is suitable for long-term clinical application.