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柯萨奇病毒系细小核糖核酸病毒群中的肠道病毒,B组含有6种与各种不同的肌肉疾病特别是心肌炎有关的血清型.作者通过纯化的病毒基因组RNA的逆转录和分子克隆杂交技术制备的柯萨奇病毒B特异性探针检测骨骼肌活检标本中是否存在病毒RNA.在2例多发性肌炎的成年患者、7例幼年皮肌炎、4例杜兴氏肌营养不良和6例正常对照者中进行.结果在9例炎性肌病患者活检标本中5例柯萨奇B病毒RNA阳性,而4例杜兴氏肌营养不良和6例对照者则均
Coxsackie virus is a group of enterovirus in the picornavirus group, and group B contains 6 serotypes associated with a variety of different muscle diseases, especially myocarditis. By means of reverse transcription of purified viral genomic RNA and molecular cloning hybridization Coxsackievirus B-specific probes were used to detect the presence of viral RNA in skeletal muscle biopsies. In 2 adult patients with polymyositis, 7 cases of juvenile dermatomyositis, 4 cases of Duchenne muscular dystrophy and 6 normal controls.Results 5 cases of Coxsackie B virus RNA were positive in the biopsy specimens of 9 cases of inflammatory myopathy patients and 4 cases of Duchenne muscular dystrophy and 6 cases of controls were