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目的:以关木通为例,探讨中药不同入药形式对其毒性成分含量的影响。方法:以3.7mmol·L-1磷酸缓冲液(pH2.55)-乙腈为流动相,260nm为检测波长,采用RP-HPLC-DAD方法测定以粉末、水煎液2种形式入药的关木通中马兜铃酸Ⅰ、马兜铃酸Ⅱ、马兜铃酸Ⅳa的含量情况。结果:关木通水煎液中马兜铃酸Ⅰ,Ⅱ,Ⅳa的煎出率分别为药材粉末中含量的53.4%,75.5%,61.9%;而在水煎后的药渣中马兜铃酸Ⅰ,Ⅱ和Ⅳa的残余量分别相当于粉末中含量的22.3%,15.7%和30.3%;3种马兜铃酸其余的约10%-25%可能在水煎过程中被破坏了;马兜铃酸Ⅰ在水煎液中仍为主要的马兜铃酸类成分。结论:不同入药形式对关木通中的毒性成分含量有很大的影响;应根据毒性成分的性质而选择合适的入药形式,以此来减少中药毒性成分对人体的损害。
Objective: To investigate the effects of different traditional Chinese medicines on the content of toxic components in Guan Mu Tong. METHODS: 3.7 mmol·L-1 phosphate buffer (pH2.55)-acetonitrile was used as the mobile phase, 260 nm was the detection wavelength, and RM-HPLC-DAD method was used to determine the use of powder and decoction as a method for the determination of the drug. Acacia acid I, aristolochic acid II, aristolochic acid IVa content. Results: The decoction rates of aristolochic acid I, II, IVa in decoction of Guan Mu Tong were 53.4%, 75.5% and 61.9% of the content of medicinal powder, respectively. Aristolochic acid I was found in decocted decoction. The residual amounts of II and IVa correspond to 22.3%, 15.7% and 30.3% of the powder contents, respectively; the remaining about 10% to 25% of the 3 kinds of aristolochic acid may be destroyed during decoction; Acid I remains the main aristolochic acid component in decoction. Conclusion: The different modes of application have a great influence on the content of toxic components in Guan Mu Tong; the appropriate form of medicine should be selected according to the nature of the toxic components, so as to reduce the harm to the human body caused by toxic components of Chinese Herbs.