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1例21岁女性因家庭争吵试图自杀而自行吞服普罗帕酮50片(50 mg/片)。2 h后出现头晕、乏力入院。血液毒物分析示普罗帕酮浓度为0.023 mg/L。心电图提示窦性心律,完全右束支传导阻滞。给予洗胃、导泻、补液以及肾上腺素,同时行血液滤过及血浆置换治疗。入院后4 h患者出现I型呼吸衰竭,立即给予经口气管插管,机械通气辅助呼吸。入院第2天行血浆置换治疗2 h(置换血浆共2000 ml),其后血液普罗帕酮浓度为0.002 mg/L,遂停止血液净化治疗。第3天心电图检查恢复正常,呼吸机脱机,改予鼻导管吸氧,患者病情平稳。第7天患者痊愈出院。
A 21-year-old woman self-absorbed propafenone 50 (50 mg / tablet) by attempting to commit suicide due to family quarrel. 2 h after dizziness, fatigue, admission. Blood poison analysis showed that propafenone concentration was 0.023 mg / L. Electrocardiogram prompted sinus rhythm, complete right bundle branch block. To gastric lavage, catharsis, rehydration and adrenaline, while hemodilution and plasma exchange treatment. 4 h after admission patients with type I respiratory failure, immediately given by orotracheal intubation, mechanical ventilation assisted breathing. On the second day after admission, plasma exchange was performed for 2 hours (total 2000 ml of plasma replacement), followed by blood propafenone concentration of 0.002 mg / L. Day 3 ECG returned to normal, respirator offline, changed to nasal catheter oxygen, patients with stable disease. On the 7th day, the patient was discharged.