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为观察及比较对乙酰氨基酚和布洛芬用于治疗儿童发热的效果和副作用,对感染所致的104例发热患儿随机分成两组分别给予对乙酰氨基酚和布洛芬治疗。结果:两者均能有效地降低儿童的体温,布洛芬组的退热有效率(87.0%)高于对乙酰氨基酚组(71.0%),存在显著性差异(X~2=3.90,P<0.05),两组副作用均少,常见胃肠道反应,比较无显著性差异(X~2=3.31,P>0.05)。提示在短期使用的情况下,对乙酰氨基酚和布洛芬是安全有效的儿童退热药物,布洛芬退热效果优于对乙酰氨基酚。
To observe and compare the effects and side effects of acetaminophen and ibuprofen in the treatment of fever in children, 104 children with fever caused by infection were randomly divided into two groups and were given acetaminophen and ibuprofen respectively. Results: Both of them were effective in lowering the body temperature in children. The effective rate of fever in the ibuprofen group (87.0%) was significantly higher than that in the acetaminophen group (71.0%), with significant difference (X ~ 2 = 3.90, P <0.05). There were few side effects and common gastrointestinal reactions in both groups. There was no significant difference (X ~ 2 = 3.31, P> 0.05). It is suggested that paracetamol and ibuprofen are safe and effective antipyretic drugs for children in short-term use, and ibuprofen is superior to acetaminophen in antipyretic effect.