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本文采用小鼠精子试验和小鼠睾丸DNA合成抑制试验,检测了JX-1对雄性生殖细胞的致突变作用。实验结果表明JX-1对小鼠精子总数、精子活动率及精子畸形率均无统计学意义的增加,与小鼠睾丸DNA合成抑制试验阴性反应一致。作者认为JX-1对雄性生殖细胞为一种非诱变剂。
In this paper, murine sperm test and mouse testicular DNA synthesis inhibition test were used to test the mutagenic effect of JX-1 on male germ cells. The experimental results showed that JX-1 had no statistically significant increase in the number of spermatozoa, sperm motility, and sperm deformity rate, which was consistent with the negative test of DNA synthesis inhibition test in mice. The authors believe that JX-1 is a non-mutagenic agent for male germ cells.