胆汁淤滞是指胆汁不能进入十二指肠,按传统概念可将其分为肝内胆汁淤滞和肝外胆汁淤滞。在本文,作者对肝内胆汁淤滞的新进展作一概述。生理学方面胆汁形成过程主要包括胆盐依赖过程和胆盐非依赖过程。胆盐是胆小管内胆汁的主要成份。已证明肝细胞摄取胆酸是一主动过程,必须同时伴随钠离子转运。胆小管的基膜和侧膜含有Na~+K~+ATP酶,此酶维持小叶电化梯度以摄取胆酸。晚近资料表明胆小管基膜和侧膜的Na~+/H~+交换可因重碳酸盐分泌碍障而受到影响。胆汁的其他成份,如有机阴离子(胆红素、酚溴酞、药物等)经不同受体被肝脏摄取。在肝细胞内,胆酸与胞 Cholestasis refers to the bile can not enter the duodenum, according to the traditional concept can be divided into intrahepatic cholestasis and extrahepatic cholestasis. Here, the authors outline the recent advances in intrahepatic cholestasis. Physiological aspects of bile formation include bile-salt-dependent processes and bile-salt-independent processes. Bile salt is the main component of bile duct bile. It has been demonstrated that uptake of bile acids by hepatocytes is an active process and must be accompanied by sodium ion transport. The basal and lateral membranes of the bile duct contain Na ~ + K ~ + ATPase, which maintains the leaflet galvanic gradient to take cholic acid. Recent data suggest that the Na ~ + / H ~ + exchange in the basilar membrane and lateral membrane may be affected by bicarbonate secretion disorders. Other components of bile, such as organic anions (bilirubin, phenol bromophthalide, drugs, etc.) are taken up by the liver via different receptors. In hepatocytes, bile acids and cells