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目的观察不同治疗方法对绝经后妇女老年性阴道炎的疗效,探讨欧维婷对该病的治疗作用和安全性。方法将近年于我院诊治的老年性阴道炎患者纳入回顾性研究,根据用药不同分为欧维婷组、倍美力组和甲硝唑组,比较用药12周后各组患者疗效、不良反应发生情况及生活质量。结果①欧维婷组和倍美力组患者症状体征缓解率高,两组比较差异无统计学意义(P>0.05);两组缓解率均高于甲硝唑组(P<0.05)。②欧维婷组与倍美力组复发率均较低,两组比较差异无统计学意义(P>0.05);两组复发率均低于甲硝唑组(P<0.05)。③欧维婷组与倍美力组患者阴道pH值显著下降,两组比较差异无统计学意义(P>0.05);改善程度均优于甲硝唑组(P<0.05)。④治疗12周后,欧维婷组与倍美力组患者阴道清洁度显著改善,两组比较差异无统计学意义(P>0.05);但改善情况均优于甲硝唑组(P<0.05)。⑤三组患者治疗前后子宫内膜厚度均无显著变化(P>0.05)。⑥欧维婷组与倍美力组生活质量改善情况比较差异无统计学意义(P>0.05),但均高于甲硝唑组(P<0.05)。结论对于老年性阴道炎的治疗应在抑制细菌生长的基础上使用雌激素制剂以增加阴道抵抗力。
Objective To observe the curative effect of different treatment methods on senile vaginitis in postmenopausal women and to explore the therapeutic effect and safety of Ouwei Ting on the disease. Methods The patients with senile vaginitis diagnosed and treated in our hospital in recent years were included in the retrospective study. According to the different drugs, they were divided into Ouwei Ting group, Beimei group and metronidazole group. The curative effect and adverse reaction of each group were compared 12 weeks after treatment And quality of life. Results ① The rates of symptom and symptom relief were significantly higher in Ovivting group and Beometrid group than those in metronidazole group (P> 0.05). There was no significant difference between the two groups (P> 0.05). ② The recurrence rates of Ovivting group and Beimei group were both lower than those of the metronidazole group (P <0.05). There was no significant difference between the two groups (P> 0.05). (3) The vaginal pH of Ouwei Ting group and Beimei Li group were significantly decreased. There was no significant difference between the two groups (P> 0.05). The improvement was better than that of metronidazole group (P <0.05). ④ After 12 weeks of treatment, the vaginal cleanliness of Ouwei Ting group and Beimei Li group was significantly improved. There was no significant difference between the two groups (P> 0.05), but the improvement was better than that of metronidazole group (P <0.05). ⑤ Three groups of patients before and after treatment, no significant changes in endometrial thickness (P> 0.05). ⑥ There was no significant difference in quality of life between Ouweiting group and Beimei group (P> 0.05), but both were higher than those of metronidazole group (P <0.05). Conclusion The treatment of senile vaginitis should be based on the inhibition of bacterial growth based on the use of estrogen preparations to increase vaginal resistance.