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睾酮替代疗法可以提高男性血清睾酮至正常水平,从而提高男性更年期患者的生活质量,然而长期使用睾酮替代疗法的风险依然存在。对于有心血管并发症的患者,应该慎用睾酮替代疗法。睾酮替代疗法可以增加男性体内前列腺特异抗原的浓度,但是并不增加前列腺癌的发病率;小样本临床试验证明睾酮替代疗法可以改善下尿路症状,但是机制不清;由于缺乏长期观察文献了解红细胞增多、睡眠呼吸暂停这两个不良反应对患者的影响,因此,长期使用睾酮替代疗法患者需要检查红细胞比容,观注其睡眠情况。
Testosterone replacement therapy can raise men’s serum testosterone to normal levels, thereby improving the quality of life in male menopause patients, but the risk of long-term use of testosterone replacement therapy persists. For patients with cardiovascular complications, testosterone replacement therapy should be used with caution. Testosterone replacement therapy can increase the concentration of prostate-specific antigen in men but does not increase the incidence of prostate cancer; small sample clinical trials have shown that testosterone replacement therapy can improve symptoms of lower urinary tract, but the mechanism is unclear; due to the lack of long-term observation of the literature to understand red blood cells Increased, sleep apnea two adverse effects on patients, therefore, long-term use of testosterone replacement therapy patients need to check the hematocrit, watching their sleep.