内源性或外源性的有毒物质,大多经肝细胞的作用使其毒性消失、减低或结合转化为可溶性物质,以利于排泄。因此%肝功能不良时能影响药物的代谢,而导致中毒。同时,药物也容易导致肝损害,这是临床用药需要十分注意的问题。肝脏对药物代谢的影响药物最重要的排泄途径是肾脏。脂溶性药物很易透过肾小管上皮细胞又被重吸收。为使之迅速排泄,机体必须将脂溶性药物转变为水溶性物质,使之失去 Endogenous or exogenous toxic substances, mostly by the role of liver cells so that its toxicity disappeared, reduced or combined into soluble substances, in order to facilitate excretion. Therefore,% liver dysfunction can affect the metabolism of drugs, which led to poisoning. At the same time, drugs can easily lead to liver damage, which is a problem that needs attention in clinical medication. Effects of the liver on drug metabolism The most important route of excretion of drugs is the kidneys. Lipophilic drugs are easily reabsorbed through renal tubular epithelial cells. To allow rapid excretion, the body must convert fat-soluble drugs into water-soluble substances to lose