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目的通过临床数据分析和血清蛋白质检测,探索血清蛋白质与肺结核病发病的关系,并通过单/双肺分组,揭示其与疾病严重程度的相关性,阐明其在肺结核病理改变中的作用。方法对94例肺结核病患者和41例健康对照者的临床资料进行分析,同时采用ELISA检测结核病患者和健康对照组的触珠蛋白(haptoglobin,HP)、基质蛋白酶抑制剂-1(tissue inhibitor of metalloproteinases-1,TIMP-1)和脯氨酸肽酶(prolidase,PEPD)。结果肺结核病患者组血清HP、PEPD含量分别为(1 501.05±1 118.91)μg/ml和(1 267.70±1 050.94)mU/ml,健康对照组分别为(814.08±844.76)μg/ml和(863.36±563.29)mU/ml,两组差异均有统计学意义(tHP=2.665,P=0.010<0.01;tPEPD=2.128,P=0.035<0.05)。肺结核病患者单、双肺损害组与健康对照组血清HP含量分别为(1 413.38±994.66)μg/ml、(1 597.08±1 258.93)μg/ml和(814.08±844.76)μg/ml,三组间的差异有统计学意义(F=3.690,P=0.030)。三组血清TIMP-1含量分别为(12 647.99±11 826.39)ng/ml、(26 507.13±18 928.79)ng/ml和(16 742.51±11 569.64)ng/ml,差异有统计学意义(F=3.787,P=0.029);双肺损害组明显高于单肺损害组(t=2.479,P=0.017)。三组血清PEPD含量分别(947.63±540.65)mU/ml、(1 594.89±1 320.46)mU/ml和(863.36±563.29)mU/ml,三组间的差异有统计学意义(F=8.253,P<0.01)。结论肺结核病患者血清HP、TIMP-1、PEPD蛋白与肺结核病发病、病理改变存在关联,血清蛋白质水平可以反应肺结核病的严重程度。
Objective To explore the relationship between serum protein and pulmonary tuberculosis through clinical data analysis and serum protein detection. To reveal the correlation between serum protein and pulmonary tuberculosis through single / double lung groupings and to elucidate its role in the pathological changes of pulmonary tuberculosis. Methods The clinical data of 94 patients with pulmonary tuberculosis and 41 healthy controls were analyzed. The levels of haptoglobin (HP), tissue inhibitor of metalloproteinases (MMP) -1 in tuberculosis patients and healthy controls were detected by ELISA. -1, TIMP-1) and prolidase (PEPD). Results The serum levels of HP and PEPD in patients with pulmonary tuberculosis were (1 501.05 ± 1 118.91) μg / ml and (1 267.70 ± 1050.94) mU / ml, respectively, and those in healthy controls were (814.08 ± 844.76) μg / ml and ± 563.29) mU / ml, the differences between the two groups were statistically significant (tHP = 2.665, P = 0.010 <0.01; tPEPD = 2.128, P = 0.035 <0.05). The levels of serum HP in patients with pulmonary tuberculosis, lung injury group and healthy control group were (1 413.38 ± 994.66) μg / ml, (1 597.08 ± 1 258.93) μg / ml and (814.08 ± 844.76) μg / ml respectively The difference was statistically significant (F = 3.690, P = 0.030). The serum levels of TIMP-1 in the three groups were (12 647.99 ± 11 826.39) ng / ml, (26 507.13 ± 18 928.79) ng / ml and (16 742.51 ± 11 569.64) ng / ml respectively, with statistical significance (F = 3.787, P = 0.029). The lung injury group was significantly higher than the single lung injury group (t = 2.479, P = 0.017). The levels of serum PEPD in the three groups were (947.63 ± 540.65) mU / ml, (1 594.89 ± 1 320.46) mU / ml and (863.36 ± 563.29) mU / ml respectively <0.01). Conclusion Serum levels of HP, TIMP-1 and PEPD in patients with pulmonary tuberculosis are associated with the pathogenesis and pathological changes of pulmonary tuberculosis. Serum protein level can reflect the severity of pulmonary tuberculosis.