目的：探讨瑞巴匹特对大鼠多种急性溃疡模型的保护作用。方法：瑞巴匹特（３，１０，３０ｍｇ／ｋｇ）连续灌胃给药１５次对水浸应激性溃疡、吲哚美辛型溃疡、幽门结扎型溃疡的影响。结果：可降低大鼠水浸应激性溃疡的胃粘膜损伤，溃疡抑制率分别为８１％、３４３％及５８４％；对吲哚美辛致溃疡的抑制率为３７７％、６４１％及７２３％。对大鼠幽门结扎型溃疡的抑制率分别为３８５％、２８７％及６５４％。但对大鼠的胃液量、总酸度、总酸排出量无显著抑制作用。结论：瑞巴匹特具有明显的抗溃疡作用 Objective: To investigate the protective effect of rebamipide on various acute ulcer models in rats. Methods: The effects of rebamipide (3, 10, 30 mg / kg) for 15 times on the stress ulcer, indomethacin ulcer and pyloric ligation ulcer were studied. Results: Gastric mucosal lesion was relieved in rats with water immersion stress ulcer, the inhibitory rates of ulcer were 81%, 343% and 584%, respectively. The inhibition rate to indomethacin-induced ulcer was 371. 7%, 641% and 723%. The inhibitory rates of pylorus ligation in rats were 385%, 287% and 654%, respectively. However, the gastric juice volume, total acidity, total acid output no significant inhibitory effect. Conclusion: Rebapept has obvious anti-ulcer effect