论文部分内容阅读
用兔侧脑室给药后观察了 －阿片受体特异性拮抗剂ＩＣＩ１７４，８６４和 阿片受体特异性拮抗剂Ｎｏｒ－Ｂｉｎａｌｔｏｒｐｈｉｍｉｎｅ（Ｎｏｒ－ＢＮＩ）对失血性休克兔血流动力学指标的影响，旨在初步阐明新型阿片受体特异性拮抗剂是否具有抗休克作用。结果显示，ＩＣＩ１７４，８６４（５０ ｇ，ｉｃｖ）和Ｎｏｒ－ＢＮＩ（５０ｇ，ｉｃｖ）均可显著改善失血性休克兔各血流动力学指标，包括血压（ＭＡＰ），左室内压（ＬＶＳＰ），左室内压最大上升和下降速度（±ｄｐ／ｄｔｍａｘ），心肌收缩速度（Ｖｃｅ４０，Ｖｐｍ）和心肌收缩向量环面积（Ｌｏ）。结果表明，特异性 和 阿片受体拮抗剂有一定的抗休克作用，值得进一步研究。
The effects of ICI174,864, an opioid receptor specific antagonist, and Nor-Binaltorphimine (Nor-BNI), a selective opioid receptor antagonist, on hemodynamics in hemorrhagic shock rabbits In the initial elucidation of new opioid receptor antagonists have anti-shock effect. The results showed that all the hemodynamic indices of hemorrhagic shock including ICI174, 864 (50 g, icv) and Nor-BNI (50 g, icv), including blood pressure (MAP), left ventricular pressure (LVSP) (± dp / dtmax), myocardial contractile velocity (Vce40, Vpm) and myocardial systolic vector annulus (Lo). The results show that specificity and opioid receptor antagonists have some anti-shock effect, worth further study.