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为探讨多药耐药基因的表达产物P170 糖蛋白在急性白血病异常表达的临床意义 ,用免疫细胞化学间接免疫荧光法 (APAAP法 )检测 30例急性白血病 (AL)患者。结果 :P170 糖蛋白在 30例急性白血病患者中有 9例表达 ,其中15例难治复发性白血病患者有 10例表达 ,其阳性表达率明显增高 ,化疗缓解率较阴性者明显减低 (P <0 0 5 )。表明P170 糖蛋白异常表达与肿瘤生物学行为关系密切 ,已成为提示急性白血病患者预后的有用指标之一。
To explore the clinical significance of the expression of multidrug resistance gene expression product P170 glycoprotein in acute leukemia, 30 patients with acute leukemia (AL) were examined by immunocytochemistry indirect immunofluorescence assay (APAAP method). RESULTS: P170 glycoprotein was expressed in 9 of 30 patients with acute leukemia. Among them, 15 patients with refractory relapsed leukemia were found to express 10 cases. The positive expression rate was significantly higher, and the chemotherapy remission rate was significantly lower than that of negative patients (P < 0). 0 5 ). It shows that the abnormal expression of P170 glycoprotein is closely related to the biological behavior of tumors, and has become one of the useful indicators to predict the prognosis of patients with acute leukemia.