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目的探讨外周血中内皮祖细胞与椎动脉支架植入术后再狭窄之间的相关性。方法选取行椎动脉支架植入术的患者127例患者为研究对象,其中发生再狭窄者68例。分别测定两组患者外周血中内皮祖细胞的数量及活性。结果椎动脉支架植入术后再狭窄组外周血中内皮祖细胞的数量为4.99±1.53,明显低于对照组的17.21±3.90,差异有统计学意义(P<0.05);再狭窄患者外周血中内皮细胞的增值倍数为1.09±0.58,明显低于对照组患者的2.21±0.46,且差异有统计学意义(P<0.05);再狭窄患者外周血中内皮祖细胞的数量与狭窄程度成明显的负相关(γ=-0.87,P<0.05),数量越多,狭窄程度越低。结论外周血中内皮祖细胞在椎动脉支架植入术后再次狭窄发生过程中扮演重要作用,存在明显的相关性。
Objective To investigate the correlation between peripheral blood progenitor cells and restenosis after vertebral artery stent implantation. Methods A total of 127 patients undergoing vertebral artery stent implantation were enrolled in this study. Among them, 68 patients had restenosis. The number and activity of endothelial progenitor cells in peripheral blood were measured in two groups. Results The number of EPCs in the restenosis group was 4.99 ± 1.53, which was significantly lower than that of the control group (17.21 ± 3.90, P <0.05). The restenosis volume The multiplication factor of endothelial cells was 1.09 ± 0.58, which was significantly lower than that of the control group (2.21 ± 0.46) (P <0.05). The number and stenosis of endothelial progenitor cells in the patients with restenosis (Γ = -0.87, P <0.05). The greater the number, the lower the degree of stenosis. Conclusion Peripheral blood endothelial progenitor cells play an important role in restenosis after vertebral artery stenting. There is a clear correlation between them.