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本研究利用QUANTIMET—970图象分析仪对26例胆管癌细胞核形态学进行了测定。并探讨了胆管癌细胞核形态学与其TNM分期、组织病理学分级、肿块大小、浸润性和淋巴转移等生物学行为的关系。研究结果表明:胆管癌细胞核内DNA含量和异型性的大小可作为判断其预后的客观指标;胆管癌肿块的大小与其癌细胞核内DNA含量成正比,且与DNA分布有关;胆管癌细胞核的异型性和DNA分布为探讨不同性别患者的胆管癌发病率提供了一个线索;胆管癌细胞核DNA倍体与其术后生存率的关系尚需进一步研究。
In this study, 26 cases of bile duct cancer cell nuclear morphology were measured using a QUANTIMET-970 image analyzer. The relationship between the nuclear morphology of cholangiocarcinoma cells and their TNM stage, histopathological grade, tumor size, invasiveness and lymphatic metastasis was discussed. The results showed that the size of DNA in the nucleus of the bile duct cancer cells can be used as an objective indicator to judge its prognosis. The size of bile duct cancer is proportional to the DNA content in the nucleus of the cancer cell and is related to the distribution of DNA; the abnormality of the bile duct cancer cell nucleus. DNA and DNA distribution provide a clue to explore the incidence of cholangiocarcinoma in patients of different genders; the relationship between nuclear DNA ploidy and postoperative survival rate of bile duct cancer cells needs further study.