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目的探讨2型糖尿病合并牙周病脂联素的变化及与颈动脉内膜-中膜厚度的关系。方法 60例2型糖尿病合并牙周病患者(T2DM+牙周病),50例无牙周病的糖尿病患者(T2DM),测定两组人群空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂联素水平,并测量颈动脉内膜-中膜厚度(IMT)。同时计算体重指数(BMI)、胰岛素抵抗指数(HOMA-IR),分析2型糖尿病合并牙周病IMT与FPG、FINS、血脂、脂联素的关系。结果 2型糖尿病合并牙周病患者FPG、FINS、TG、IMT、HOMA-IR水平高于无牙周病的糖尿病患者,而HDL-C、脂联素水平低于无牙周病的糖尿病组,差异有统计学意义(P﹤0.05或P﹤0.01)。且IMT与年龄、糖尿病病程、FPG、TC、TG、LDL-C、FINS、HOMA-IR、BMI呈正相关(P﹤0.05或P﹤0.01),与HDL-C、脂联素呈负相关(P﹤0.01)。结论 2型糖尿病合并牙周病患者血清脂联素水平低于无牙周病的糖尿病组,且低脂联素水平与2型糖尿病合并牙周病患者IMT密切相关。
Objective To investigate the changes of adiponectin in type 2 diabetic patients with periodontal disease and its relationship with intima-media thickness of carotid artery. Methods Sixty patients with type 2 diabetes mellitus (T2DM + periodontal disease) and 50 patients without periodontal disease (T2DM) were enrolled in this study. The levels of fasting blood glucose (FPG), fasting insulin (FINS), total cholesterol TC, TG, HDL-C, LDL-C, and adiponectin were measured and carotid intima-media thickness (IMT) . The body mass index (BMI) and insulin resistance index (HOMA-IR) were also calculated. The relationship between IMT and FPG, FINS, lipids and adiponectin in type 2 diabetic patients with periodontal disease was analyzed. Results The levels of FPG, FINS, TG, IMT and HOMA-IR in type 2 diabetic patients with periodontal disease were higher than those without periodontal disease, while the levels of HDL-C and adiponectin in diabetic patients with periodontal disease were lower than those without periodontal disease. The difference was statistically significant (P <0.05 or P <0.01). The IMT was positively correlated with age, duration of diabetes, FPG, TC, TG, LDL-C, FINS, HOMA-IR and BMI (P <0.05 or P <0.01) <0.01). Conclusions Serum levels of adiponectin in type 2 diabetic patients with periodontal disease are lower than those without periodontal disease, and the level of adiponectin is closely related to IMT in type 2 diabetic patients with periodontal disease.