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脂肪酸合酶是生物体内催化合成内源性脂肪酸的关键酶,其在正常细胞和组织中的含量很低,但在肿瘤细胞中,脂肪酸合酶有较高的表达。对脂肪酸合酶过表达的肿瘤细胞使用脂肪酸合酶抑制剂,可诱导肿瘤细胞凋亡,而对正常细胞无影响,这对肿瘤的治疗和预防提供了新的作用靶点。文中综述了脂肪酸合酶抑制剂的研究进展。
Fatty acid synthase is a key enzyme catalyzing the synthesis of endogenous fatty acids in vivo, and its content in normal cells and tissues is very low. However, fatty acid synthase is highly expressed in tumor cells. Fatty acid synthase overexpression of tumor cells using fatty acid synthase inhibitor, can induce tumor cell apoptosis, but no effect on normal cells, which provides a new therapeutic target for the prevention and treatment of tumors. The article reviews the research progress of fatty acid synthase inhibitors.