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目的探讨中青年急性脑梗死患者颈动脉粥样硬化斑块性质与高敏C-反应蛋白(hs-CRP)之间的关系。方法对海南省农垦总局医院确诊中青年急性脑梗死92例住院患者和同期住院的非脑血管病患者90例分别应用高频多普勒超声检测颈动脉斑块,同时采用全自动化仪分别检测其血hs-CRP浓度;将脑梗死组依斑块性质分为不稳定斑块组、稳定斑块组及无斑块组,非脑血管病为对照组,对所检测结果分析各组间的检出率和颈动脉粥样硬化斑块类型与hs-CRP相关性。结果青中年急性脑梗死患者的斑块检出率明显高于对照组(P<0.01),不稳定斑块组明显高于稳定斑块组及无斑块组(P<0.01),稳定斑块组高于无斑块组(P<0.01),脑梗死3个亚组中,不稳定斑块组hs-CRP水平明显高于稳定斑块组及无斑块组(P<0.05),稳定斑块组hs-CRP水平高于无斑块组(P<0.05)。结论青中年急性脑梗死患者hs-CRP水平及颈动脉斑块有其相关性,尤其与不稳定斑块密切相关。
Objective To investigate the relationship between carotid atherosclerotic plaque and high-sensitivity C-reactive protein (hs-CRP) in young and middle-aged patients with acute cerebral infarction. Methods Ninety-two inpatients with acute cerebral infarction and 90 non-cerebrovascular patients hospitalized in Hainan Provincial Bureau of Land Reclamation were enrolled in this study. Carotid artery plaque was detected by high-frequency Doppler sonography. At the same time, Blood hs-CRP concentration; the cerebral infarction group according to plaque properties are divided into unstable plaque group, stable plaque group and no plaque group, non-cerebrovascular disease as the control group, the test results analysis of the inter-seizure Outcome and Carotid Atherosclerotic Plaque Types Associated with hs-CRP. Results The detection rate of plaque in young middle-aged patients with acute cerebral infarction was significantly higher than that in control group (P <0.01). The unstable plaque group was significantly higher than that in stable plaque group and no plaque group (P <0.01) The levels of hs-CRP in unstable plaque group were significantly higher than those in stable plaque group and non-plaque group (P <0.05), stable The level of hs-CRP in plaque group was higher than that in non-plaque group (P <0.05). Conclusion There is a correlation between hs-CRP levels and carotid plaques in young and middle-aged patients with acute cerebral infarction, especially in unstable plaques.