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目的观察三维适形放疗联合化疗及消癌平治疗局部晚期食管癌的临床疗效观察,为临床治疗提供指导。方法选择80例符合入组标准的局部晚期食管癌患者随机分为观察组40例和对照组40例,对照组给予三维适形放疗治疗+同步化疗,观察组在对照组的基础上再静脉点滴消癌平,进行近期疗效评价,观察患者放射性食管炎、放射性肺炎、血液毒性发生情况,进行患者治疗前后KPS生活质量评分。结果观察组和对照组近期疗效分别为97.5%与70.0%(P<0.01);观察组放射性肺炎、血液毒性发生率明显低于对照组(均P<0.01);观察组治疗后KPS生活质量评分明显高于对照组(P<0.05)。结论三维适形放疗联合化疗及消癌平治疗局部晚期食管癌可有效降低放疗的毒副反应,提高患者放疗耐受性及近期疗效,生活质量明显提高,起到增效减毒作用,保证治疗方案顺利完成,值得临床推广使用。
Objective To observe the clinical efficacy of three-dimensional conformal radiotherapy combined with chemotherapy and Xiaochangping in the treatment of locally advanced esophageal cancer and provide guidance for clinical treatment. Methods Eighty patients with locally advanced esophageal cancer who met the inclusion criteria were randomly divided into observation group (40 cases) and control group (40 cases). The control group received three-dimensional conformal radiation therapy plus synchronous chemotherapy. The observation group was treated with intravenous drip Xiaochang Ping, the recent evaluation of efficacy, observation of patients with esophagitis, radiation pneumonitis, hematological toxicity occurred before and after treatment KPS quality of life score. Results The short-term curative effects of the observation group and the control group were 97.5% and 70.0%, respectively (P <0.01). The incidences of radiation pneumonitis and hematotoxicity in the observation group were significantly lower than those in the control group (all P <0.01) Significantly higher than the control group (P <0.05). Conclusions The three-dimensional conformal radiotherapy combined with chemotherapy and Xiaowanping can effectively reduce the side effects of radiotherapy and radiotherapy to improve the patient’s radiotherapy tolerance and the short-term curative effect, and the quality of life is obviously improved, which can enhance the effect and attenuate the toxic effects and ensure the treatment Successful completion of the program is worthy of clinical promotion and use.