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目的 从神经内分泌学角度探讨慢性束缚应激的发生机制及疏肝中药对其调节作用。方法 建立慢性束缚应激大鼠模型 ,通过行为学实验评估大鼠应激状态下的行为变化 ,并测定大鼠肾上腺、胸腺指数及体内单胺递质含量变化 ,通过对疏肝中药复方柴胡疏肝散的防治作用的观察探讨中药复方的作用机理。结果 柴胡疏肝散可对抗应激引起的体能及情绪改变 ,并对各种单胺递质有不同的调节作用。结论 柴胡疏肝散在一定程度上调节了慢性束缚应激模型动物的行为表现 ,而且使不同组织单胺递质含量呈现动态变化趋势 ,提示其参与慢性束缚应激的内在调节
Objective To investigate the mechanism of chronic restraint stress and the regulating effect of soothing liver herbs on them from the perspective of neuroendocrinology. METHODS: A rat model of chronic restraint stress was established. Behavioral changes in rats under stress were assessed by behavioral experiments. Rat adrenal glands, thymus index, and monoamine transmitter content in the body were measured. Observing the preventive and therapeutic effects of Shugansan on the mechanism of action of Chinese herbal compound. Results Bupleurum Shugan Powder can resist physical and emotional changes caused by stress, and have different regulatory effects on various monoamine transmitters. Conclusion Bupleurum Shugan San can regulate the behavior of chronic restraint stress model animals to a certain extent, and make the content of monoamine neurotransmitters in different tissues show dynamic trends, suggesting that it participates in the internal regulation of chronic restraint stress.