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[目的]探索我国人群谷胱甘肽转移酶类(GSTs)基因多态性与慢性苯中毒的易感性的关系。[方法]2007年,采用Meta分析方法对国内外1994~2004年关于谷胱甘肽转移酶T1(GSTT1)和谷胱甘肽转移酶M1(GSTM1)基因多态性与慢性苯中毒易感性研究的文献进行综合定量分析。[结果]收集符合要求的文献7篇,其中关于GSTT1基因的文献5篇,累积病例379例、对照376例;关于GSTM1基因的文献6篇,累积病例432例、对照429例。GSTT1按固定效应模型计算合并的OR值为1.31(95%CI为0.98~1.75),GSTT1基因多态和慢性苯中毒易感性之间没有明显的统计学意义(P>0.05);GSTM1基因按照随机效应模型计算合并的OR值为1.85(95%CI为1.10~3.12),GSTM1基因多态性与慢性苯中毒易感性之间有统计学意义(P<0.05)。[结论]我国人群的GSTT1基因多态性与慢性苯中毒易感性没有明显的关系,GSTM1基因多态性与慢性苯中毒易感性存在一定的关系。
[Objective] To explore the relationship between glutathione transferase (GSTs) gene polymorphism and susceptibility to chronic benzene poisoning in China. [Methods] In 2007, we analyzed the polymorphisms of glutathione S-transferase T1 (GSTT1) and glutathione transferase M1 (GSTM1) and susceptibility to chronic benzene poisoning at home and abroad from 1994 to 2004 by Meta analysis The literature for comprehensive quantitative analysis. [Results] There were 7 articles that meet the requirements, of which 5 articles were published on GSTT1 gene, 379 cases were cumulative and 376 cases were control. Six articles on GSTM1 gene were found, including 432 cases of accumulation and 429 cases of control. The OR of GSTT1 was 1.31 (95% CI: 0.98-1.75), and there was no significant difference between GSTT1 gene polymorphism and chronic benzene poisoning susceptibility (P> 0.05) The odds ratio of GSTM1 gene polymorphism and chronic benzene poisoning was statistically significant (P <0.05). The odds ratio of GSTM1 gene polymorphism was 1.85 (95% CI 1.10-3.12). [Conclusion] There is no obvious relationship between GSTT1 gene polymorphism and susceptibility to chronic benzene poisoning in Chinese population. There is a certain relationship between GSTM1 gene polymorphism and chronic benzene poisoning susceptibility.