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探讨细胞增殖活性与成人型喉乳头状瘤生物学行为的关系。采用抗增殖细胞核抗原（PCNA）单克隆抗体PC10，ABC免疫组化法和银染技术，评价其细胞增殖活性。结果：经PCNA阳性反应计算出的PCNA增殖指数与核仁形成区嗜银蛋白（AgNORs）计数间存在显著的相关性。经统计学分析有显著差异（P＜0．05）。提示：PCNA表达和统AgNORs计数可作为喉部良、恶性病变的鉴别，检测癌前病变及观察肿瘤生物学行为较好的参考指标。
To investigate the relationship between cell proliferation activity and biological behavior of adult laryngeal papilloma. PCNA monoclonal antibody PC10, ABC immunohistochemistry and silver staining were used to evaluate the cell proliferative activity. RESULTS: There was a significant correlation between PCNA proliferation index and count of AgNORs in PCNA. The statistical analysis showed significant differences (P <0.05). It is suggested that the expression of PCNA and the count of AgNORs can be used as a reference for the identification of benign and malignant lesions of the larynx, the detection of precancerous lesions and the observation of the biological behavior of the tumor.