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[目的]探讨胰岛素样生长因子Ⅰ型受体(IGF-ⅠR)在乳腺癌中的表达及其临床意义。[方法]免疫组化方法检测20例正常乳腺组织、20例乳腺良性肿瘤和86例乳腺恶性肿瘤组织中IGF-ⅠR的表达。[结果]①乳腺恶性肿瘤IGF-ⅠR的阳性率及强阳性率明显高于乳腺良性肿瘤(χ2=10.512,P=0.001;χ2=23.591,P=0.000),高于正常乳腺组织(χ2=29.341,P<0.05);②IGF-ⅠR在伴淋巴结转移的乳腺癌中表达明显高于无淋巴结转移的乳腺癌(χ2=3.950,P=0.047);③IGF-ⅠR表达与患者年龄、绝经情况、肿瘤大小、ER和PR表达情况、临床分期、病理类型无明显相关性。[结论]IGF-ⅠR在乳腺癌的发生发展过程中发挥着重要作用,有可能成为临床诊断和判断预后的一个重要指标。
[Objective] To investigate the expression of insulin-like growth factor type I receptor (IGF-ⅠR) in breast cancer and its clinical significance. [Methods] The expression of IGF-ⅠR in 20 cases of normal breast tissues, 20 cases of benign breast tumors and 86 cases of breast malignant tumors were detected by immunohistochemistry. [Results] ① The positive rate and strong positive rate of IGF-ⅠR in breast malignant tumors were significantly higher than those in benign breast tumors (χ2 = 10.512, P = 0.001; χ2 = 23.591, P = 0.000) , P <0.05). ② The expression of IGF-ⅠR in breast cancer with lymph node metastasis was significantly higher than that in breast cancer without lymph node metastasis (χ2 = 3.950, P = 0.047) There was no significant correlation between ER and PR expression, clinical stage and pathological type. [Conclusion] IGF-ⅠR plays an important role in the occurrence and development of breast cancer and may become an important index for clinical diagnosis and prognosis.